Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.

5 a [ 5 ];), and loss of a single App allele in the Npc1 brain ( Npc1 −/− /App +/− ) was sufficient to trigger an additional increase in IP-10/CXCL10 expression. In addition, one IFN-γ downstream cytokine, RANTES/CCL5, displayed an increased trend in 3-week-old Npc1 −/− /App +/+ mice compared with wild-type littermates, but did not reach statistical significance (Fig. 5 b).

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