Genetic association of interleukin 18 (-607C/A, rs1946518) single nucleotide polymorphism with asthmatic children, disease severity and total IgE serum level.

Finally, analysis of the association between IL-18 (C/A, rs 1946518) genotypes and serum level of IgE in both patients and control groups revealed that the serum level of IgE was higher in asthmatic patients carrying the mutant heterozygous AA genotype compared to other asthmatic patients carrying the CA and CC genotypes respectively, however, the difference between groups did not reach statistical significance.

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