An Ancient Mutation in the <i>TPH1</i> Gene is Consistent with the Changes in Mammalian Reproductive Rhythm.

For the six combinations of the four cytochrome P450 protein isoforms, the LRT value of CYP1A1/CYP1A2 was 0.176 ( p > 0.05), indicating that the structure and function of CYP1A1 and CYP1A2 proteins did not diverge significantly in these mammals, while the protein divergence of the other five combinations was extremely significant ( p < 0.01).

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The activity of TPH1-1325T was five times higher than that of TPH1-1325C, and their difference was highly significant ( p < 0.01). 3.

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Whether in the retina or pineal, the expression of the TPH1 gene showed a trend of low during the day and high during the night [ 26 ], which was consistent with the rule of melatonin synthesis [ 27 ].

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