The Changing Landscape of Pharmacotherapy for Diabetes Mellitus: A Review of Cardiovascular Outcomes.

Int J Mol Sci · 2019 · PMC6928800 · PMID 31766545

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did not reach statistical significanceno p-value reported

The University Group Diabetes Program study in 1970 was terminated early due to excessive mortality that did not reach statistical significance in the sulphonylurea-treated group and led to tolbutamide being withdrawn from the market [ 49 ].

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