The Value of Programmed Death Ligand 1 Expression in Cancer Patients Treated with Neoadjuvant Chemotherapy.

40 Expression of PD-L1 in tumour cells of Her2-positive breast cancer tumours showed a trend of association with pCR but did not reach significance. 41 The evaluation of several predictive markers revealed that 20 out of 27 PD-L1-positve invasive breast cancer cases showed excellent response to NAC using the Residual Cancer Burden score. 41 The mechanisms underlying the differential response amongst different molecular types of breast carcinoma may be due to the differing biology of the three types i.e. the tumours may or may not be immunogenic.

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showed induction of PD-L1 expression by cytokines as interferon (IFN)-γ or other inflammatory stimuli could result in attenuation of TCR/CD28–mediated T-cell activation which may be significant in the regulation of inflammatory or autoimmune reactions. 8 PD-L1, also called B7-H1, is a member of B7 molecules which are involved in the regulation of T-cell response either through stimulation or inhibition. 9 PD-L1 is generally widely expressed in different tissues from different lineages inc

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