NPY₁R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression.

H&E staining of the subcutaneous and epigonadal adipose tissue depots showed a trend toward smaller epigonadal and subcutaneous cell size in the mice treated with tesa-NPY (3), whereas the mean adipocyte diameter for all of the other mice was comparable ( Figure 7 D). 3.6 Tesa-NPY influences metabolic parameters in db/db mice In addition to the body weight and body composition, several metabolic parameters were measured after treatment with tesa, tesa-NPY (3), [F 7 , P 34 ]-NPY (2), or vehicle/untreated.

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