Is There an Independent Role of TERT and NF1 in High Grade Gliomas?

Transl Oncol · 2020 · PMC6940679 · PMID 31891871

Europe PMC DOI

hedged sentences

0.0850

closest p · 1.7× alpha

0.1000

boldest claim

The sentences

showed a trendp = 0.085so close (0.05 < p ≤ 0.1)

Mutated TP53 univariately showed a trend for worse survival (HR = 1.63, 95% CI 0.94–2.85, p = 0.085), whereas increase in pt's age and in the number of mutated genes per tumor was associated with higher risk of death (HR = 1.05, 95% CI 1.02–1.07, p < 0.001 and HR = 1.09, 95% CI 1.02–1.16, p = 0.009, respectively) ( Supplemental Table S4 ).

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a trend towards significancep < 0.10so close (0.05 < p ≤ 0.1)

Similar to the analyses conducted for the entire cohort, we assessed the impact of TERT muts upon adjustment for all parameters that showed significance or revealed a trend towards significance ( p < 0.10) in the univariate analysis (age, NF1 mutational status, TP53 mutational status, number of mutated genes per tumor, and MGMT promoter methylation status).

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