Methyl (Alkyl)-Coenzyme M Reductases: Nickel F-430-Containing Enzymes Involved in Anaerobic Methane Formation and in Anaerobic Oxidation of Methane or of Short Chain Alkanes.

16 The primary isotope effect is quite significant, reflecting that in the methane activating direction a thiyl radical abstracts a hydrogen atom from methane, which is a very endothermal reaction (Δ H o ≈ 70 kJ/mol) and which is not observed in nonenzymatic reactions because follow-up reactions of the thiyl radicals such as dimerization are much faster in solution.

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