Varying effects of tyrosine kinase inhibitors on platelet function-A need for individualized CML treatment to minimize the risk for hemostatic and thrombotic complications?

As shown in Figure 4 , in vitro dasatinib treatment resulted in a nonsignificant trend toward decreased expression of the active fibrinogen receptor after activation with CRP‐XL.

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Bosutinib had opposite effects, with a significant trend toward decreased alpha‐granule release but increased lysosomal release, in response to PAR‐APs and ADP, respectively (Figure 5 A,D).

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