Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration.

In cardiac nerve bundles, %AAT of 8-OHdG-ir showed a trend (p < 0.07, η p 2 = 0.367) toward an overall effect of treatment, which was significant when treatment was considered in combination with region (treatment x region: %AAT, p < 0.04, η p 2 = 0.309; OD, p < 0.03, η p 2 = 0.312).

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The effect of region showed a trend toward significance (%AAT, p < 0.08, η p 2 = 0.175; OD, p > 0.186, η p 2 = 0.124).

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In this context, what was the criterion to classify a given result as a trend? This information should be included in the manuscript, because a p = 0.08 was considered a trend (lines 601 to 604), whereas a p = 0.09 was not (lines 583 to 586).” << We thank the reviewer for this question and the opportunity to address how we define a statistical trend.

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