Serum Carnosinase-1 and Albuminuria Rather than the <i>CNDP1</i> Genotype Correlate with Urinary Carnosinase-1 in Diabetic and Nondiabetic Patients with Chronic Kidney Disease.

Of note, the median urinary CN-1 concentrations of healthy individuals were significantly lower compared to those of T2DM patients with macroalbuminuria ( p < 0.0001), and healthy individuals showed with borderline significance lower urinary CN-1 concentrations compared to the nondiabetic group with macroalbuminuria ( p = 0.05) (data not shown).

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Macroalbuminuric patients in the CKD group displayed trends for increased serum creatinine and lower eGFR in comparison to CKD patients with normo- or microalbuminuria, but these differences did not reach statistical significance.

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