Protein-based amide proton transfer-weighted MR imaging of amnestic mild cognitive impairment.

Additionally, the age dependency analyses revealed that these cross-sectional APTw/MTR signals had an increasing trend with age in most brain regions for normal controls, but a decreasing trend with age in most brain regions for aMCI patients.

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In three remaining ROIs (the entorhinal cortex, the gray matter in the frontal lobe, and the caudate nucleus), the APTw values in the aMCI group showed a trend toward higher levels, but the increases were not statistically significant, compared to the normal control group ( P > 0.05).

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