In addition, the cooling cohort showed a nonsignificant trend toward a higher percentage of patients with good clinical outcomes; however, due to the limited sample size, these findings will require further verification.
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Evidence and opportunities of hypothermia in acute ischemic stroke: Clinical trials of systemic versus selective hypothermia.
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No significant differences in adverse side effects were reported between the two groups, and the combination therapy group showed a trend toward better functional outcome at 6 months, warranting a future clinical trial.