CD4 downregulation function declined most slowly (0.64% per year), whereas HLA downregulation and SERINC5 function declined somewhat more rapidly (1.97% and 1.29% per year, respectively, though the latter did not reach statistical significance).
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Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study.
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