Surprisingly, starting from day 34 when the first 0.25-mg pellet is implanted, the PWT in the E-increase group took a decreasing trend and this downregulation continued with the other 4 0.25-mg pellets implanted in succession.
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Estrogen modulation of pain perception with a novel 17β-estradiol pretreatment regime in ovariectomized rats.
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The sentences
Thermal nociception was seldom affected as was concluded by Sanoja et al [ 2 ]; however, based on our observations, OVX rats showed a trend of decreased thermal pain threshold 3 weeks following the surgery (data not shown).