Over-expression of EGFR was indicative of a longer overall survival (OS) for M0 patients (p = 0.00209) whereas an inversion of this trend was observed for M1 patients although it did not reach statistical significance (p = 0.107, Figure S6 B-C ).
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The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor.
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