A role for phagocytosis in inducing cell death during thymocyte negative selection.

Negative selection in response to OVAp was also slightly reduced on Timd4 -/- thymic slices, although the difference did not reach statistical significance ( Figure 4c ).

also in 111,027 other papers

While there is a slight trend towards reduced death in the WT+AP20187+OVAp group in Figure 1B, there is a clear significant difference between this group and the MAFIA+AP20187+OVAp, suggesting that treatment with drug has the biggest impact on MAFIA slices, in which phagocytes are susceptible to deletion, and any potential off-target impacts of the drug on negative selection are relatively minimal.

also in 4,078 other papers