New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products.

Environ Health Perspect · 2019 · PMC6957284 · PMID 31854200

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a clear trendno p-value reported

Other limitations of the available data on HAAs for read-across were the reliance on in vitro studies, the limited number of in vivo genetic toxicity or other mechanistic data available, the lack of a clear trend in the BMDLs as a measure of cancer potency, and a negative cancer bioassay for monochloroacetic acid (the only mono-HAA tested for carcinogenicity).

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