A preliminary study of resting brain metabolism in treatment-resistant depression before and after treatment with olanzapine-fluoxetine combination.

PLoS One · 2020 · PMC6957341 · PMID 31931515

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

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marginally significantP = .05actually significant

However, baseline right hemisphere BA25 metabolism showed a marginally significant correlation with change from baseline MADRS, whereby higher baseline metabolism predicted better response to O/F therapy ( r = 0.68, P = .05).

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approached significanceno p-value reported

However, a broader ROI along the VMPFC approached significance despite the small sample size.

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