Self-associated tau was reduced in the hippocampus Analysis of the hippocampal homogenates from the male and female htau mice using the DA9 mono-antibody ELISA for tau showed a statistically significant decrease in the level of self-associated tau in the group with the highest level of compound in the brain for the mixed male and female mice or male mice alone, whereas female mice showed a trend in reduction of self-associated tau ( Fig. 2 ).
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In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice.
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Total and phosphorylated soluble tau levels in the forebrain and hippocampus The hippocampal heat stable fractions in the confirmatory study showed statistical equivalence for levels of total tau and phosphorylated tau, but in the forebrain there was a highly significant increase of tau phosphorylated at the CP13 and RZ3 epitopes in the heat stable fractions of mice with 25 ng/g brain levels of compound ( Fig. 9 A-D).