Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids.

Mol Metab · 2020 · PMC6957843 · PMID 32029233

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In males, this homeostasis was ensured by hepatic ERα; indeed, the lack of this receptor in LERKO males led to a significant increase (or showed a trend to augment) in the majority of FFA, an effect boosted by the HFD ( Figure 5 B).

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