Long-term efficacy after closure of patent foramen ovale for ischemic neurological events in young adults: A systematic review and meta-analysis.

Medicine (Baltimore) · 2020 · PMC6959863 · PMID 31914059

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Compared with PFO closure of older patients, PFO closure of younger patients reduced the risk of composite outcome in RCT subgroup (OR: 0.68; 95% CI: 0.29–1.57; P = .37) and subgroup demarcated by 45 years of age (OR: 0.50; 95% CI: 0.23–1.09; P = .08), but did not reach statistical significance.

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