Hypermethylation-associated downregulation of microRNA-4456 in hypersexual disorder with putative influence on oxytocin signalling: A DNA methylation analysis of miRNA genes.

Epigenetics · 2020 · PMC6961682 · PMID 31542994

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0001

boldest claim

The sentences

borderline significantp < 10E-05actually significant

Two CpG-sites were borderline significant in HD – cg18222192 (MIR708)( p < 10E-05, p FDR = 5.81E-02) and cg01299774 (MIR4456)(p < 10E-06, p FDR = 5.81E-02).

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nominally significantno p-value reported

Subsequently, binomial tests were performed in R using the function ‘binom.test’, contrasting for each gene the number of nominally significant CpG-sites to the total number of probes annotated to each gene transcript not taking the direction of the methylation change into account.

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