The Use of Analgesics during Vaccination with a Live Attenuated <i>Yersinia pestis</i> Vaccine Alters the Resulting Immune Response in Mice.

pestis VAX cells, the IFN-γ levels were only reduced in splenocytes collected from vaccinated mice that were treated with analgesics and stimulated with C12 cells, but the reduction did not reach statistical significance ( Figure 4 and Table S6, Supplementary Materials ).

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Stimulation of splenocytes with irradiated CO92 cells promoted a stronger IFN-γ response compared to splenocytes stimulated with C12 cells, or VAX cells in C57BL/6 mice for all vaccinated groups, although these differences failed to reach significance.

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