Breast Cancer Cells and PD-1/PD-L1 Blockade Upregulate the Expression of PD-1, CTLA-4, TIM-3 and LAG-3 Immune Checkpoints in CD4<sup>+</sup> T Cells.

Vaccines (Basel) · 2019 · PMC6963740 · PMID 31614877

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showed a trendno p-value reported

However, MDA-MB-468 cells upregulated PD-1 expression and showed a trend towards upregulated levels of CTLA-4, TIM-3 and LAG-3 expression in CD4 + CD25 − T cells ( Figure 2 C).

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