Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years.

From the distribution analysis, testosterone showed a significant trend across the years ( Figure 1B ), together with a seasonal distribution ( Figure 1A ), confirmed at the Box-Ljung test (X-squared = 10.989, degrees of freedom = 8, p -value = 0.022).

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In particular, we show here an increasing trend of environmental temperatures across the years of observation, related to increasing testosterone serum levels.

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