Characterization of binding, functional activity, and contractile responses of the selective 5-HT_1F receptor agonist lasmiditan.

Lasmiditan only showed a trend to decrease blood pressure at the highest (supratherapeutic dose), which, based on the affinity of lasmiditan (see Table 1 ), could be due to a non‐selective activation of prejunctional 5‐HT 1D receptors and subsequent inhibition of sympathetic perivascular nerves (Villalón et al., 1998 ).

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