showed a trendp = 0.07
In addition to being associated with invasive margin, stromal and intra‐epithelial CD3 + density, high biopsy intra‐epithelial CD3 + density was also associated with intra‐epithelial CD8 + density and the combined CD3 + /CD8 + assessment (both p < 0.001), and showed a trend towards an association with invasive margin and stromal CD8 + density ( p = 0.07 and p = 0.058 respectively; Table 3 ).