Effect of sex and polymorphisms of CYP2B6 and UGT1A9 on the difference between the target-controlled infusion predicted and measured plasma propofol concentration.

reported a strong trend towards the association of the CYP2B6 G516T variant with high blood propofol concentrations after a single bolus dose [ 26 ].

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The association of female sex was marginally significant on the minimal adjustment with baseline characteristics (model 5, Table 4 ); however, the association was substantially attenuated and became not significant in the full-adjusted model with clinical factors (model 6, Table 4 ).

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