Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids.

ANPEP was chosen as the most significant DEG in our dataset, whilst KIF16B , ARGHAP32 , ECE1 and GNL3 were highly significant DEGs and were also genes associated with nearby differential accessibility.

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To gain a further understanding of the relationship between these differential peaks, an enrichment analysis was again performed using the ToppFun function of ToppGene; this identified a nominally significant enrichment of differential peaks associated with malignant tumor of colon (q = 8 E-02 ).

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