Association between hereditary predisposition to common cancers and congenital multimalformations.

If syndromal, multiple and chromosomal abnormalities were grouped together under the label “extended,” their proportion compared to unique malformations yield significant differences ( P = 0.014) according to parental mutation status and a significant trend was objectivized ( P = 0.0011) from the first to the fourth group (Table 2 ): Children of deleterious mutation carriers had a 10‐fold risk of “extended” malformation in comparison to the control group.

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Overall, no difference was found between the four groups of parents ( P = 0.28) although the association between chromosomal malformations and older fathers was close to significance ( P = 0.06).

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