Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy.

Also, the seemingly increased survival of Irf7 -/- mice treated with cGAMP in survival as compared to untreated controls, did not reach statistical significance ( Fig 6M ). cGAMP-mediated ISG induction is dependent on IFNAR1 The induction of ISGs requires IFN-I binding and signaling through IFNAR1 to induce an anti-viral state [ 6 , 7 ].

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