Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts.

5A , the suppressive effect of AIBP on HIV replication was significantly lower in cells from HLA-B*35 donors on day 3 postinfection and had completely disappeared by day 5 p.i., whereas AIBP-mediated suppression was still highly significant ( P < 0.001) in two other donors with non-B*35 genotype.

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However, fusion with HIVΔNef of MDMs exposed to exNef showed a trend of being reduced by AIBP, although the difference did not reach significance ( P = 0.0874).

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