Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton.

Similar to in vitro findings, old female mice demonstrated a lower percentage (−35% to –50%) and spatial density (−35% to −60%) of osteocytes with PMD in the femur or tibia caused by treadmill exercise as compared to young females, as measured by either intracellular endogenous mouse albumin or intracellular exogenous Evans Blue (Figure 1 c–h), although immunostaining‐based measurements of albumin did not quite reach statistical significance ( p = .08). 2.2.

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Primary osteocyte cultures from old mice contained significantly fewer slow‐repairing osteocytes (−36% female, −47% male, p = .011) and tended to have more fast‐repairing osteocytes as compared to cultures from young mice for both male and female groups, although the increased abundance of fast‐repairing osteocytes did not reach statistical significance (+57% female, +40% male, p = .12; Figure 2 e).

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