As previously reported ( 3 ), mutation of sarA limited virulence in both strains as assessed by reactive bone formation and cortical bone destruction, although in this experiment, the reduction in cortical bone destruction observed with the UAMS-1 sarA mutant did not reach statistical significance ( Fig. 11 ).
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The Impacts of <i>msaABCR</i> on <i>sarA</i>-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus.
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