Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects.

In skeletal muscle, tissue estrone concentrations were comparable between groups (5804±967 pg/gm in WT(WT) mice versus 4336±392 pg/gm in WT(ArKO) mice, p = 0.15), but tissue 17β-estradiol concentrations were ~30% lower in WT(ArKO) mice relative to WT(WT) controls, although the difference did not achieve significance (5489±660 pg/gm in WT(WT) mice versus 3836±599 pg/gm in WT(ArKO) mice, p = 0.08; Fig 7C ).

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The description of these data could be re-worded to state that the mean value of ERalpha mRNA was higher in the WT(ArKO) mice than the WT mice however this did not reach statistical significance (P=0.09).

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