3T3-L1 fibroblast cells treated with low-dose of methyltransferase inhibitor methylthioadenosine showed a quite significant decline in adipocyte differentiation, which is due to the removal of epigenetic sign from the promoters, thus, proved the important role of histone modification in regulating adipogenesis [ 113 ].
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Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells.
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