Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone.

Alternatively, the differentially expressed lncRNAs that were colocated with mRNAs were determined to be significantly enriched in metabolic-related pathways, including steroid hormone biosynthesis, starch and sucrose metabolism, pentose and glucuronate interconversions, and metabolism of xenobiotics by cytochrome P450 ( Figure 5(e) , Supplementary ); the metabolism pathways and NF κ b signaling pathway were also notably associated with these differentially expressed mRNAs and however did not reach statistical significance ( Figure 5(e) , Supplementary ).

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