Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.

Cell Stress Chaperones · 2020 · PMC6985055 · PMID 31900865

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did not reach statistical significanceno p-value reported

A similar pattern was observed with RGFP109, except the difference between RGFP109 and in combination with arimoclomol did not reach statistical significance (Fig. 7b ).

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