highly significantp < 0.01
A total of 14 genes had significant negative effects on CHA (unadjusted p < 0.05), and seven genes had highly significant negative effects on CHA (Tukey’s adjusted p < 0.01), including SPN, C16orf54, SEZ6L2, ASPHD1 , TAOK2, INO80E , and FAM57B .