Spontaneous activity in the waiting brain: a marker of impulsive choice in attention-deficit/hyperactivity disorder?

There were highly significant positive correlations between QDQ scores and F-WAIT activity in insula (MNI[ x / y / z ] = −35/20/5; r delay aversion = .57, p < 0.001; r temporal discounting = .57, p < .001) and inferior frontal gyrus (MNI[ x / y / z ] = −35/25/0; r delay aversion = .51, p = 0.001; r temporal discounting = .53, p

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For controls the REST to C-WAIT effect failed to reach significance after stringent control for multiple testing (pseudo t = 6.76, corrected p = 0.07), albeit the attenuations were localized to similar regions.

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Nominally significant REST to C- and F-WAIT reductions occurred in DMN-related regions, including precuneus, superior parietal lobule, postcentral gyrus and medial frontal gyrus (F-WAIT: pseudo t = 5.07, corrected p = 0.20; C-WAIT: pseudo t = 6.16, corrected p = 0.15) but these were not significant when p values were adjusted for multiple testing.

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