Barely Significant
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Periostin plays a critical role in the cell cycle in lung fibroblasts.

Respir Res · 2020 · PMC6993476 · PMID 32000779

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Interestingly, although expression of E2F1 and E2F3 tended to be downregulated but did not reach statistical significance by periostin silencing in MRC-5 cells, it was significantly downregulated in IPF lung fibroblasts.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.