Financial Stress Interacts With <i>CLOCK</i> Gene to Affect Migraine.

Main Effects of Stress Factors on MigraineID All three stress factors (CHA, RLE, FINANC) showed highly significant ( p < 0.0001) main effects on migraineID with more severe stress increasing the prevalence of migraineID.

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To assess our nominally significant findings we used three methods: (a) the gold standard Bonferroni correction to adjust p-values for multiple testing in our 12 main analyses [additive, dominant and recessive models of CLOCK SNP main effects and SNP × stress factor (CHA, RLE, or FINANC) interactions on migraineID in the total sample

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