An improved method for detecting telomere size differences in T-lymphocyte interphases from older people with Down syndrome with and without mild cognitive impairment.

Again, the effect of group was highly significant and no other effect approached significance, F (1,16) = 25.5, P <0 .0002, and verify the usefulness of the CY3 probe as an internal reference for quantification of telomere length.

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A t -test for dependent samples confirmed that this difference was highly significant [ t (9) = 5.76, P < 0.0003] replicating our previously reported findings of high correspondence between telomere length and clinical status.

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