A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiency.

Here we show that only females and not males show a highly significant correlation between an increase in TARP and a decrease in synGAP in the PSDs of Syngap1 +/- rodents.

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However, the significance of Spearman’s r between levels of NLG-2 and synGAP in PSDs shows only a strong trend toward an inverse correlation ( Figure 6A ).

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In data from HET rats at 7.5 weeks, the inverse correlation is very close to significance; at 12.5 weeks, it is less significant, but still shows a trend.

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