a clear trendp = 0.07
However, the authors found that beyond 1 month (OR 3.46 for abstinence in HE group compared with control), a growing number of patients in both groups relapsed, the overall significant differences between HE and control persisted until 6 months (OR 2.59) and retained a clear trend until 12 months (OR 1.66, p = 0.07) [48] .