Effects of chronic prazosin, an alpha-1 adrenergic antagonist, on anxiety-like behavior and cortisol levels in a chronic unpredictable stress model in zebrafish (<i>Danio rerio</i>).

Exploratory behavior in the novel tank test A t -test for independent means indicated a marginally significant effect of chronic unpredictable stress for the number of entries to the top zone ( t (48) = − 1.920, p = 0.061; CUS < untreated), a significant effect on the total time spent in the top zone ( t (48) = − 2.129, p = 0.038; CUS < untreated), but no significant difference in the distance traveled in the top zone ( t (48) = − 1.309, p = 0.197; Table 2 ).

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Although these results did not reach statistical significance, the fish subjected to chronic unpredictable stress and subsequently were vehicle-treated had lower levels of cortisol than untreated-vehicle controls, which is similar to the pattern of results observed in Experiment 1.

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