Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.

Oncoimmunology · 2020 · PMC6996562 · PMID 32064174

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Notably, anti-PD1 antibody plus the CM-siStat3 combination showed a trend toward suppressed B16 tumor growth and synergistically improved mice survival with respect to the CM-siStat3 alone ( Figure 4(b ,c)).

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