Obeticholic acid and INT-767 modulate collagen deposition in a NASH in vitro model.

Sci Rep · 2020 · PMC6997404 · PMID 32015483

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showed a trendno p-value reported

Treatment with OCA was able to induce a clear dose-dependent increase of MMP-2 and 9 activity at 96 hours, while at 144 hours, despite a clear reduction in collagen content, the treated samples showed a trend towards a reduction in MMP-2 and 9 activity compared to FFA-treated samples.

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