Surgical and Surgeon-Related Factors Related to Long-Term Survival in Esophageal Cancer: A Review.

The Dutch TIME-trial showed the 3-year overall survival in the totally minimally invasive esophagectomy group (59 patients) to be 40.4% versus 50.5% in the open esophagectomy group (56 patients), but this indication of a difference failed to reach statistical significance in the multivariable regression model (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.54–1.44). 5 The French MIRO trial indicated a better 3-year overall survival in the hybrid minimally invasive esophagectomy group (103 patients) than in the open esophagectomy group (104 patients) (67.0%

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